Vyper · Ability 2 · 28s cooldown
Lethal Venom
Updated ·Refreshed daily from public match data·Methodology
HeroVyper →What does Lethal Venom do in Deadlock?
Lethal Venom is Vyper's ability 2 on a 28-second cooldown with 3s venom buildup duration, 20 minimum venom damage, 140 max venom damage. Inject a target with lethal venom. After a delay the venom triggers, dealing Spirit Damage. The damage is increased by the target's missing health. Lethal Venom will ignore Petrify's damage block.
Upgrades: 1 AP — +31.5 Max Venom Damage; 2 AP — -40% Incoming Healing and -12s Cooldown; 5 AP — Bullets also build up Lethal Venom.
In the most played Vyper skill order (52.6% win rate over 8.6K games), Lethal Venom takes its first point at step 3 and gets 4 of the first 12 points, making it the second ability players max.
Full numbers below; for items and lane matchups see the Vyper build, or compare cooldowns on the all-abilities table.
Base values, before items
Lethal Venom stats
Cooldown
28s
Venom Buildup Duration
3s
Minimum Venom Damage
20
Max Venom Damage
140
Health for Max Damage
30%
Buildup Decay Time
5s
Ability points
Lethal Venom upgrades
- 1 AP
+31.5 Max Venom Damage
- 2 AP
-40% Incoming Healing and -12s Cooldown
-40% Incoming Healing · -40% Incoming Healing · -12s Cooldown
- 5 AP
Bullets also build up Lethal Venom
+4.5% Buildup Per Shot
Most played Vyper skill order
When to level Lethal Venom
In the most played Vyper skill order (52.6% win rate over 8.6K games), Lethal Venom takes its first point at step 3 and gets 4 of the first 12 points, making it the second ability players max.
Lethal Venom patch history
Gameplay Update - 04-30-2026 · April 30, 2026
- – Lethal Venom cooldown increased from 24s to 28s
- – Lethal Venom T2 increased from -8s Cooldown to -12s
- – Lethal Venom cast range reduced from 15m to 10m and now scales with boons (0.2)
Other Vyper abilities
Heal
Abilities like Lethal Venom
FAQ
What is the cooldown of Lethal Venom?＋
Lethal Venom has a 28-second base cooldown before cooldown items or upgrades. One of its upgrades lowers it further — see the upgrade list above.
What are the Lethal Venom upgrades?＋
1 AP: +31.5 Max Venom Damage 2 AP: -40% Incoming Healing and -12s Cooldown 5 AP: Bullets also build up Lethal Venom
When should you level Lethal Venom?＋
In the most played Vyper skill order (52.6% win rate over 8.6K games), Lethal Venom takes its first point at step 3 and gets 4 of the first 12 points, making it the second ability players max.
Which hero has Lethal Venom?＋
Lethal Venom is Vyper's ability 2. Vyper is a assassin whose other abilities are Screwjab Dagger, Slither, Petrifying Bola.